ABSTRACT
Quinazoline derivatives were reported to have different biological activities, including analgesic, antipyretic, antimicrobial, fungicidal, antidepressant and other central nervous system affecting activities[1-7]. The use of quinazoline derivative as starting material for the design and synthesis of new heterocyclic compounds with the aim of preparing potent biologically active compounds is a subject of recent interest[8, 9]Now, we report a facile synthesis of several heterocyclic compounds containig pyrazole, oxadiazine, phthalazine and triazine to test them against different microorganisms
Subject(s)
Pyrazoles , Phthalazines , Microbial Sensitivity TestsABSTRACT
1 -AZIDO-4-phenyl-1,4-butanedione 2 proved to be a convenient precursor for the synthesis of a variety of heterocyclic systems through its treatment with some acidic and basic reagents. For example, 2-benzazepine-1,5-dione 3, 1,3-oxazolane-2,4-dione 4a, 1,3-thiazolane-2,4-dione 4b, 1,3-oxazol-5-one 5, quinazoline-2,4-dione 7, 4,6-diaryl-2-pyrimidineones 9a-d, 2,5-bis-substituted amino-1,3,4-oxadiazole II,5-aryl-2-N-substituted amino-1,3,4-oxadiazoles 13a,b, 1,2,4-triazol-3-ones 14a,b, 1,3-benzoxazine-2,4 [3H]-dione 15 and 1,3,4-oxadiazol-2[3H]-ones 16a,b
Subject(s)
Azides/chemistry , Aziridines/chemistry , Triazoles/chemistry , Acids, HeterocyclicABSTRACT
The wide range of pharmacological activities of chromones as stimulants [1], diuretic[2], antibiotics[3] and anticancer [4] agents have stimulated recent interest in the synthesis of derivatives of this ring system. Claisen condensation of 2,4-diacetyl resorcinol with diethylmalonate in the presence of piperidine gave 2,4-bis-[l,3- dioxo-butanyl] resorcinol [1]. The IR spectrum of [1] showed absorption bands at 1660-1635 cm[-1] [upsilon CO, ketone] and 3400-3180 cm[-1] [upsilon OH, br.]. The [1]H NMR spectrum of [1] exhibited signals at b 2.0 - 2.9 [sxs, 6 H, 2 CH3], 6.1 [s, 4H, 2 CH[2] 6.4 [s, 2H, olefinic protons] 7.5-7.7 [2s, 2 H, non-equivalent Ar-H] and 11.3 [s, 2H, 2 OH phenolic]